• Sayed E Wahezi, Moorice A Caparo, Ria Malhotra, Lakshman Sundaram, Kevin Batti, Prince Ejindu, Ratnakar Veeramachaneni, Magdalena Anitescu, Corey W Hunter, Tahereh Naeimi, Fadi Farah, and Lynn Kohan.
• Multidisciplinary Pain Program, Montefiore Medical Center, Bronx, New York, USA. Electronic address: swahezi@montefiore.org.
• Neuromodulation. 2024 Jan 1; 27 (1): 475847-58.

BackgroundNeuromodulation is a standard and well-accepted treatment for chronic refractory neuropathic pain. There has been progressive innovation in the field over the last decade, particularly in areas of spinal cord stimulation (SCS) and dorsal root ganglion stimulation. Improved outcomes using proprietary waveforms have become customary in the field, leading to an unprecedented expansion of these products and a plethora of options for the management of pain. Although advances in waveform technology have improved our fundamental understanding of neuromodulation, a scoping review describing new energy platforms and their associated clinical effects and outcomes is needed. The authors submit that understanding electrophysiological neuromodulation may be important for clinical decision-making and programming selection for personalized patient care.ObjectiveThis review aims to characterize ways differences in mechanism of action and clinical outcomes of current spinal neuromodulation products may affect contemporary clinical decision-making while outlining a possible path for the future SCS.Study DesignThe study is a scoping review of the literature about newer generation SCS waveforms.Materials And MethodsA literature report was performed on PubMed and chapters to include articles on spine neuromodulation mechanism of action and efficacy.ResultsA total of 8469 studies were identified, 75 of which were included for the scoping review after keywords defining recent waveform technology were added.ConclusionsClinical data suggest that neuromodulation remains a promising tool in the treatment of chronic pain. The evidence for SCS for treating chronic pain seems compelling; however, more long-term and comparative data are needed for a comparison of waveforms when it comes to the etiology of pain. In addition, an exploration into combination waveform therapy and waveform cycling may be paramount for future clinical studies and the development of new technologies.Copyright © 2023 International Neuromodulation Society. Published by Elsevier Inc. All rights reserved.

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