• Alexandre Roux, Angela Elia, Oumaima Aboubakr, Alessandro Moiraghi, Giorgia Antonia Simboli, Arnault Tauziede-Espariat, Edouard Dezamis, Eduardo Parraga, Chiara Benevello, Houssem Fathallah, Fabrice Chretien, Catherine Oppenheim, Marc Zanello, and Johan Pallud.
• Service de Neurochirurgie, GHU Paris Psychiatrie et Neurosciences, Site Sainte Anne, Paris, France.
• Neurosurgery. 2024 Jan 8.

Background And ObjectivesWe assessed the impact of ventricular opening on postoperative complications and survival of carmustine wafer implantation during surgery of newly diagnosed supratentorial glioblastomas, isocitrate dehydrogenase (IDH)-wildtype in adults.MethodsWe performed an observational, retrospective, single-center cohort study at a tertiary surgical neuro-oncological center between January 2006 and December 2021.ResultsOne hundred ninety-four patients who benefited from a first-line surgical resection with carmustine wafer implantation were included. Seventy patients (36.1%) had a ventricular opening. We showed that ventricular opening (1) did not increase overall postoperative complication rates (P = .201); (2) did not worsen the early postoperative Karnofsky Performance Status score (P = .068); (3) did not increase the time interval from surgery to adjuvant oncological treatment (P = .458); (4) did not affect the completion of the standard radiochemotherapy protocol (P = .164); (5) did not affect progression-free survival (P = .059); and (6) did not affect overall survival (P = .142).ConclusionIn this study, ventricular opening during first-line surgical resection did not affect the survival and postoperative complications after use of carmustine wafer implantation in adult patients with a newly diagnosed supratentorial glioblastoma, IDH-wildtype. This warrants a prospective and multicentric study to clearly assess the impact of the ventricular opening after carmustine wafer implantation in glioblastoma, IDH-wildtype.Copyright © Congress of Neurological Surgeons 2024. All rights reserved.

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