• Am. J. Med. Sci. · Jan 2019

    Pancreatic Stellate Cells Activation and Matrix Metallopeptidase 2 Expression Correlate With Lymph Node Metastasis in Pancreatic Carcinoma.

    • Yueguang Li, Tao Song, Zhen Chen, Yao Wang, Juyuan Zhang, and Ximo Wang.
    • Department of Oncological Surgery, Tianjin Hospital of ITCWM Nankai Hospital, Tianjin, China; Department of General Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
    • Am. J. Med. Sci. 2019 Jan 1; 357 (1): 162216-22.

    BackgroundThis study aimed to investigate the correlation between pancreatic stellate cell activation, matrix metallopeptidase 2 (MMP2) expression and lymph node metastasis in pancreatic carcinoma.MethodsAlpha-smooth muscle actin (ACTA2), Desmin (DES) and MMP2 were detected in 40 pancreatic carcinoma patients and 10 cases of normal pancreas tissues using immunohistochemistry. Then MMP2 and ACTA2 expression profiles in pancreatic cancer were obtained from UCSC (University of California, Santa Cruz) and SurvExpress.ResultsA total of 67.5% and 55.0% of cases positively expressed ACTA2 and DES in pancreatic carcinoma, respectively. MMP2 in pancreatic carcinoma was expressed in 55.0% of cases, and there were significant differences between the lymph node metastasis group and the lymph node nonmetastasis group, as well as invasion and noninvasion to the peripheral tissue group (P < 0.01). High throughput sequencing databases verified that ACTA2 and MMP2 gene expression were both upregulated in pancreatic carcinoma tissues.ConclusionsThe coexpression of ACTA2 and DES was related to the expression of MMP2, and positively correlated with lymph node metastasis. Activation of pancreatic stellate cells may promote the expression of MMP2 and enhance the invasion and metastasis of pancreatic carcinoma.Copyright © 2018. Published by Elsevier Inc.

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