• Cheryl L Maier, Karim Brohi, Nicola Curry, Nicole P Juffermans, Mora MiquelLidiaLDepartment of Anaesthesiology, Intensive Care and Pain Clinic, Vall d'Hebron Trauma, Rehabilitation and Burns Hospital, Autonomous University of Barcelona, Passeig de La Vall d'Hebron 119-129, 08035, Barcelona, Spain., Matthew D Neal, Beth H Shaz, VlaarAlexander P JAPJAmsterdam University Medical Centers, Amsterdam, The Netherlands., and Julie Helms.
• Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA, USA.
• Intensive Care Med. 2024 Mar 1; 50 (3): 319331319-331.

AbstractHaemorrhagic shock is frequent in critical care settings and responsible for a high mortality rate due to multiple organ dysfunction and coagulopathy. The management of critically ill patients with bleeding and shock is complex, and treatment of these patients must be rapid and definitive. The administration of large volumes of blood components leads to major physiological alterations which must be mitigated during and after bleeding. Early recognition of bleeding and coagulopathy, understanding the underlying pathophysiology related to specific disease states, and the development of individualised management protocols are important for optimal outcomes. This review describes the contemporary understanding of the pathophysiology of various types of coagulopathic bleeding; the diagnosis and management of critically ill bleeding patients, including major haemorrhage protocols and post-transfusion management; and finally highlights recent areas of opportunity to better understand optimal management strategies for managing bleeding in the intensive care unit (ICU).© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.

16 keywords...

hide…