• Am J Chinese Med · Jan 2006

    Comparative Study Clinical Trial

    Synergistic effect of ginger and nifedipine on human platelet aggregation: a study in hypertensive patients and normal volunteers.

    • Haw-Yaw Young, Jung-Chun Liao, Yuan-Shiun Chang, Yen-Lin Luo, Ming-Chin Lu, and Wen-Huang Peng.
    • Graduate Institute of Chinese Pharmaceutical Sciences, China Medical University, Taichung, Taiwan, ROC.
    • Am J Chinese Med. 2006 Jan 1; 34 (4): 545551545-51.

    AbstractIn this study, we evaluated the synergistic effect of ginger and nifedipine on anti-platelet aggregation in normal human volunteers and hypertensive patients. The results showed that the percentage of platelet aggregation induced by collagen, ADP and epinephrine in hypertensive patients was larger than that in normal volunteers. Either aspirin or ginger could potentiate the anti-platelet aggregation effect of nifedipine in normal volunteer and hypertensive patients. These results suggested that ginger and nifedipine possessed synergistic effect on anti-platelet aggregation. A combination of 1 g ginger with 10 mg nifedipine per day could be valuable for cardiovascular and cerebrovascular complication due to platelet aggregation.

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