• Sem M M Hermans, Aniek A G Lantinga-Zee, Ruud Droeghaag, Henk van Santbrink, van HemertWouter L WWLWDepartment of Orthopaedic Surgery, Zuyderland Medical Center, Heerlen, The Netherlands., Mattheus K Reinders, HoofwijkDaisy M NDMNDepartment of Anaesthesiology, Zuyderland Medical Center, Heerlen, The Netherlands., van KuijkSander M JSMJDepartment of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center, Maastricht, The Netherlands., Kim Rijkers, and Inez Curfs.
• Department of Orthopaedic Surgery, Zuyderland Medical Center, Heerlen, The Netherlands.
• Spine. 2024 Apr 1; 49 (7): 456462456-462.

Study DesignProspective, double-blind randomized controlled trial.ObjectiveIf an intraoperative single bolus of epidural bupivacaine can result in less postoperative pain following lumbar spinal decompression surgery.Summary Of Background DataAdequate postoperative pain management following lumbar spinal decompression surgery is important, as it will lead to early mobilization, less complications, and a shorter hospital stay. Opioid consumption should be limited due to their frequently accompanied side effects and their addictive nature. During the final phase of lumbar decompression surgery, the epidural space becomes easily accessible. This might be an ideal moment for surgeons to administer an epidural bolus of analgesia as a safe and effective method for postoperative pain relief.Materials And MethodsIn this trial, we compared a single intraoperative bolus of epidural analgesia using bupivacaine 0.25% to placebo (NaCl 0.9%) and its effect on postoperative pain following lumbar spinal decompression surgery. The primary outcome was the difference in Numeric (Pain) Rating Scale between the intervention and placebo groups during the first 48 hours after surgery.ResultsBoth the intervention group and the placebo group consisted of 20 randomized patients (N=40). Statistically significant lower mean Numeric (Pain) Rating Scale pain scores were observed in the intervention group in comparison with the control group (main effect group: -2.35±0.77, P =0.004). The average pain score was lower in the intervention group at all postoperative time points. No study-related complications occurred.ConclusionThis randomized controlled trial shows that administrating a bolus of intraoperative epidural bupivacaine is a safe and effective method for reducing early postoperative pain following lumbar decompression surgery.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

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