• Pain · Oct 2005

    Comparative Study Clinical Trial

    The effects of immediate-release morphine on cognitive functioning in patients receiving chronic opioid therapy in palliative care.

    • Sunjeev K Kamboj, Adrian Tookman, Louise Jones, and H Valerie Curran.
    • Clinical Psychopharmacology Unit, Sub-Department of Clinical Health Psychology, University College London, Gower Street, London, WC1E 6BT, UK.
    • Pain. 2005 Oct 1;117(3):388-95.

    AbstractMorphine and other potent opioids are frequently used in palliative care and pain management. When sustained-release (SR) opioids do not provide adequate background analgesia, additional immediate-release (IR) opioid (e.g. short-acting morphine) may be required to alleviate breakthrough or episodic pain. Despite the frequent use of IR morphine on top of SR opioids, little is known about the effects of such treatment on patients' everyday cognitive functioning. This study therefore used a double-blind, placebo-controlled, cross-over design to assess cognitive functioning in 14 patients receiving palliative care. All patients were taking SR opioid preparations and required

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