• Wisconsin medical journal · Apr 1997

    Case Reports

    Retinoic acid syndrome in acute promyelocytic leukemia.

    • D Sentero and J Hosenpud.
    • Medical College of Wisconsin, USA.
    • Wis. Med. J. 1997 Apr 1;96(4):35-8.

    AbstractAll-trans retinoic acid (ATRA) has been used successfully in inducing remission in patients with acute promyelocytic leukemia (APL). Its overall toxicity is considerably less compared to standard induction chemotherapy; however, it is associated with a high incidence of a potentially fatal symptom complex referred to as "retinoic acid syndrome." This report describes a patient with APL who developed the syndrome a few weeks after initiating induction therapy with ATRA despite being treated for hyperleukocytosis. The case illustrates the classic features of the syndrome and its dramatic response to corticosteroid treatment.

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