• World Neurosurg · Mar 2024

    The Hospital Frailty Risk Score independently predicts postoperative outcomes in glioblastoma patients.

    • Adrian E Jimenez, Sachiv Chakravarti, Jiaqi Liu, Foad Kazemi, Christopher Jackson, Gary Gallia, Chetan Bettegowda, Jon Weingart, Henry Brem, and Debraj Mukherjee.
    • Department of Neurosurgery, Columbia University Medical Center, New York, New York, United States.
    • World Neurosurg. 2024 Mar 1; 183: e747e760e747-e760.

    ObjectiveThe Hospital Frailty Risk Score (HFRS) is a tool for quantifying patient frailty using International Classification of Diseases, Tenth Revision codes. This study aimed to determine the utility of the HFRS in predicting surgical outcomes after resection of glioblastoma (GBM) and compare its prognostic ability with other validated indices such as American Society of Anesthesiologists score and Charlson Comorbidity Index.MethodsA retrospective analysis was conducted using a GBM patient database (2017-2019) at a single institution. HFRS was calculated using International Classification of Diseases, Tenth Revision codes. Bivariate logistic regression was used to model prognostic ability of each frailty index, and model discrimination was assessed using area under the receiver operating characteristic curve. Multivariate linear and logistic regression models were used to assess for significant associations between HFRS and continuous and binary postoperative outcomes, respectively.ResultsThe study included 263 patients with GBM. The HFRS had a significantly greater area under the receiver operating characteristic curve compared with American Society of Anesthesiologists score (P = 0.016) and Charlson Comorbidity Index (P = 0.037) for predicting 30-day readmission. On multivariate analysis, the HFRS was significantly and independently associated with hospital length of stay (P = 0.0038), nonroutine discharge (P = 0.018), and 30-day readmission (P = 0.0051).ConclusionsThe HFRS has utility in predicting postoperative outcomes for patients with GBM and more effectively predicts 30-day readmission than other frailty indices. The HFRS may be used as a tool for optimizing clinical decision making to reduce adverse postoperative outcomes in patients with GBM.Copyright © 2024 Elsevier Inc. All rights reserved.

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