• Yu Feng, Yunbei Yu, Kai Meng, Maocai Li, Guotao Jia, Yongya Du, Siyu Liu, Lili Gong, and Lianqing Li.
• Department of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, Liaocheng, China.
• Medicine (Baltimore). 2024 Jan 12; 103 (2): e36833e36833.

BackgroundSpindle cell tumors are rare and can occur in any organ or tissue. Due to their rarity the clinicopathological features and diagnostic protocols have not been adequately studied. However, it has become necessary to develop differential diagnosis of spindle cell tumors. Here, we report a case of a nasal spindle cell tumor diagnosed at our hospital in attempt to contribute to this gap in literature.Key Points From The CaseA male in his 30s was admitted to our hospital with nasal obstruction that had persisted for several years. Electronic fibrolaryngoscopy revealed a smooth neoplasm within the nasal cavity.Main Lessons To Be Learned From This Case ReportThe results of this case emphasize that spindle cell tumors have large morphological variations, and it is difficult to determine the origin of tumor cells using hematoxylin and eosin staining alone. Therefore, it is necessary to improve the immunohistochemistry and combine it with clinical symptoms to diagnose the disease.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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