• Jun Hyeon Park, Kyung Sik Yi, Chi-Hoon Choi, Yook Kim, Jisun Lee, Yeongtae Park, and Ok-Jun Lee.
• Department of Radiology, Chungbuk National University Hospital, Cheongju, Republic of Korea.
• Medicine (Baltimore). 2024 Jan 12; 103 (2): e36945e36945.

RationaleMyofibromas are rare benign spindle cell tumors of the soft tissue, bone, or internal organs that occur at any age. Here, we report a post-surgical thyroid bed myofibroma that mimicked a papillary thyroid carcinoma.Patient ConcernsA 56-year-old male presented with a mass in the thyroid surgical bed, detected 3 years post thyroidectomy following papillary carcinoma.DiagnosisThyroid ultrasonography revealed a well-defined, lobulated, hypoechoic, solid nodule, with large rod-like echogenic foci in the thyroid surgical bed. The development of a postoperative suture granuloma was considered. However, ultrasonography performed 12 months later showed a marked increase in the lesion size. Two fine needle aspiration cytology yielded nondiagnostic results.InterventionConsidering the possibility of local tumor recurrence, surgical resection was performed.OutcomeThe diagnosis of a myofibroma was confirmed, and no additional treatment was administered.LessonsIt is challenging to differentiate lesions occurring on the thyroid surgical bed after surgery, from recurrent thyroid cancer. A lesion measuring 6 mm, with a degree of punctate echogenicity, suggests tumor recurrence. Moreover, myofibromas are extremely rare. This case highlights that it is advisable to perform a core needle biopsy in cases of nondiagnostic fine needle aspiration results.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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