• Shilna Muttickal Swaminathan, Indu Ramachandra Rao, Mohan V Bhojaraja, Ravindra Prabhu Attur, Shivashankara Kaniyoor Nagri, Dharshan Rangaswamy, Srinivas Vinayak Shenoy, and Shankar Prasad Nagaraju.
• Department of Nephrology, Kasturba medical college, Manipal, Manipal Academy of Higher Education, Manipal-576104, Karnataka, India.
• J Natl Med Assoc. 2024 Feb 1; 116 (1): 334433-44.

AbstractDiabetic kidney disease (DKD) is the most devastating complication of diabetes mellitus. Identification of patients at the early stages of progression may reduce the disease burden. The limitation of conventional markers such as serum creatinine and proteinuria intensify the need for novel biomarkers. The traditional paradigm of DKD pathogenesis has expanded to the activation of the immune system and inflammatory pathways. Monocyte chemo-attractant protein-1 (MCP-1) is extensively studied, as a key inflammatory mediator that modulates the development of DKD. Recent evidence supports the diagnostic role of MCP-1 in patients with or without proteinuria in DKD, as well as a significant role in the early prediction and risk stratification of DKD. In this review, we will summarize and update present evidence for MCP-1 for diagnostic ability and predicting the progression of DKD.Copyright © 2023 National Medical Association. Published by Elsevier Inc. All rights reserved.

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