• Medicina clinica · Apr 2024

    Relationship between obstructive sleep apnea and type 2 diabetes mellitus.

    • Romina Abelleira, Carlos Zamarrón, Vanessa Riveiro, Ana Casal, María Elena Toubes, Carlos Rábade, Jorge Ricoy, Adriana Lama, Nuria Rodríguez-Núñez, Lucía Ferreiro, Juan Rodríguez-Ozores, and Luis Valdés.
    • Servicio de Neumología, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, España. Electronic address: abelleiraparis@hotmail.com.
    • Med Clin (Barc). 2024 Apr 26; 162 (8): 363369363-369.

    IntroductionThe association between obstructive sleep apnea (OSA) and glucose metabolism remains controversial. This study investigates the relationship between OSA and incident type 2 diabetes (DM) and prediabetes (preDM), as well as the effect of long-term CPAP (continuous positive airway pressure) treatment.MethodsFollow-up study in a retrospective clinical cohort of patients with OSA and randomly selected controls. Data on incident DM and preDM as well as CPAP were obtained from hospital records. The relationship between baseline OSA and incident DM was examined using COX regression models.ResultsThree hundred and fifty-six patients, 169 with OSA and 187 controls were followed for a median of 98 months; 47 patients (13.2%) developed DM and 43 (12.1%) developed preDM. The 5-year cumulative incidence of DM was 10.7% (6.5-13.9%). 87% of subjects with preDM in the baseline sample progressed to incident DM. It is shown that body mass index (BMI), nocturnal hypoxia and apnea hypopnea index (AHI) are risk factors for the development of DM and that CPAP reduces this risk.ConclusionsPatients with OSA have a higher risk of developing DM. The risk factors involved are BMI, nocturnal hypoxia and AHI. Regular long-term CPAP use was associated with a decreased risk.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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