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Internal medicine journal · Mar 2024
Use of a type 1 genetic risk score for classification of diabetes type in young Australian adults: the Fremantle Diabetes Study Phase II.
- DavisTimothy M ETME0000-0003-0749-7411Medical School, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.Department of Endocrinology and Diabetes, Fiona Stanley and Fremantle Hospitals Group, Perth, Western Austra, Kirsten E Peters, and Wendy Davis.
- Medical School, University of Western Australia, Fremantle Hospital, Fremantle, Western Australia, Australia.
- Intern Med J. 2024 Mar 1; 54 (3): 494498494-498.
AbstractThe applicability of a UK-validated genetic risk score (GRS) was assessed in 158 participants in the Fremantle Diabetes Study Phase II diagnosed between 20 and <40 years of age with type 1 or type 2 diabetes or latent autoimmune diabetes of adults (LADA). For type 1 versus type 2/LADA, the area under the receiver operating characteristic curve (AUC) was highest for serum C-peptide (0.93) and lowest for the GRS (0.66). Adding age at diagnosis and body mass index to C-peptide increased the AUC minimally (0.96). The GRS appears of modest diabetes diagnostic value in young Australians.© 2024 The Authors. Internal Medicine Journal published by John Wiley & Sons Australia, Ltd on behalf of Royal Australasian College of Physicians.
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