• J D Clemens, D A Sack, J R Harris, J Chakraborty, M R Khan, B F Stanton, M Ali, F Ahmed, M Yunus, and B A Kay.
• International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.
• Lancet. 1988 Jun 18; 1 (8599): 137513791375-9.

AbstractThe impact of B subunit killed whole-cell (BS-WC) and killed whole-cell-only (WC) oral cholera vaccines was assessed in a randomised double-blind trial in rural Bangladesh. 62,285 children aged 2-15 years and women aged over 15 ingested three doses of one of the vaccines or placebo. During the first year of follow-up there was a 26% reduction of all visits for treatment of diarrhoea in the BS-WC group and a 22% reduction in the WC group. The reduction of all admissions for fatal or severely dehydrating diarrhoea was 48% in the BS-WC group and 33% in the WC group. Overall mortality rates were 26% lower in the BS-WC group and 23% lower in the WC group during the first year, and reductions of mortality were observed only in women vaccinated at ages over 15 years. However, no differences in cumulative mortality were evident at the end of the second year of surveillance.

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