• Internal medicine · Mar 2024

    Case Reports

    Anaphylaxis and Severe Disseminated Intravascular Coagulation Due to Remdesivir.

    • Noriyasu Fukushima, Kazuharu Kamachi, Tomonori Sato, Keitaro Ishii, Rika Tomimasu, and Masaharu Miyahara.
    • Internal Medicine, Karatsu Red Cross Hospital, Japan.
    • Intern. Med. 2024 Mar 15; 63 (6): 873876873-876.

    AbstractA 69-year-old woman suffering with multiple myeloma developed coronavirus disease 2019 (COVID-19). Shortly after administration of remdesivir, she presented with symptoms of facial flushing, wheezing, and hypoxemia. Subsequently, thrombocytopenia and hypofibrinogenemia rapidly manifested, leading to a diagnosis of enhanced fibrinolytic-type disseminated intravascular coagulopathy (DIC). This clinical presentation was considered an immediate hypersensitivity reaction with associated coagulation abnormalities induced by remdesivir. Although remdesivir is generally considered safe and efficacious in the treatment of COVID-19, physicians should remain vigilant regarding the potential for severe adverse events associated with this medication.

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