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Randomized Controlled Trial Clinical Trial
Double-blind, randomized, placebo controlled pilot study evaluating efficacy and reactogenicity of an oral ETEC B-subunit-inactivated whole cell vaccine against travelers' diarrhea (preliminary report).
- G Wiedermann, H Kollaritsch, M Kundi, A M Svennerholm, and U Bjare.
- Institute for Specific Prophylaxis and Tropical Medicine, University of Vienna, Austria.
- J Travel Med. 2000 Jan 1; 7 (1): 272927-9.
AbstractDiarrhea caused by enterotoxigenic E.coli (ETEC) is an important health problem in developing countries and in travelers to these areas. In previous trials formulations of ETEC vaccines containing the B-subunit of cholera toxin, which is antigenically similar to the heat labile enterotoxin of ETEC, and the most prevalent colonization factor antigens of ETEC, were shown to stimulate relevant mucosal immune responses in volunteers from Sweden and Egypt.
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