• Philipp Schulte-Terhusen, Xenofon Baraliakos, and Dimitra Karagkiozidou.
• Rheumazentrum Ruhrgebiet Herne, St. Elisabeth Gruppe GmbH, Herne.
• Dtsch. Med. Wochenschr. 2024 Feb 1; 149 (3): 102105102-105.

History And Clinical Findings The 71-year-old patient reported long-standing inflammatory arthralgia due to psoriasis vulgaris. Therapy with methotrexate led to elevated liver values; the symptoms persisted under treatment with the TNFα inhibitor adalimumab.Medical Examinations Using arthrosonography and MRI, a predominantly periarticular inflammatory pattern on the wrists, metacarpophalangeal joints and proximal interphalangeal joints could be objectified without post-inflammatory stigmata of psoriatic arthritis. Laboratory diagnostics revealed an elevated anti-HCV titer with a high viral load consistent with a florid hepatitis C.Diagnosis A predominantly extrahepatic hepatitis C with associated periarthritis was diagnosed.Therapy And Course With combined, interferon-free antiviral therapy, arthralgia suspended completely.Conclusion Hepatitis C can appear through extrahepatic manifestations in the form of periarticular inflammation. Suspicious inflammatory arthralgias in psoriasis vulgaris are not conterminous with the diagnosis of psoriatic arthritis and should be evaluated by a professional rheumatologist.Thieme. All rights reserved.

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