• Huan Zhang, Shuyan Wang, and Chunnian Wang.
• Department of Pathology, Ningbo Clinical Pathological Diagnosis Center, Ningbo, China.
• Medicine (Baltimore). 2024 Jan 26; 103 (4): e36993e36993.

IntroductionPrimary mucoepidermoid carcinoma (MEC) is a common malignant neoplasm of the salivary glands, but is very rare in the pancreas. To date, only 10 cases have been reported in the literature. Because MEC of the pancreas is very rare, there is little information about its diagnosis, treatment, and metastasis. Herein, we present the eleventh case and review the relevant literature.Patient ConcernsA 65-year-old woman presented with a mass in the body of the pancreas and multiple masses in the liver on abdominal magnetic resonance imaging. The patient initially underwent EUS-guided fine-needle aspiration and was diagnosed with adenocarcinoma. After adjuvant chemotherapy, resection of the pancreatic body and tail was performed, and the tissues were pathologically, histologically, and immunochemically examined. Specific strains and gene rearrangements were analyzed.DiagnosisMucoepidermoid pancreatic cancer.InterventionAfter a 4-month course of adjuvant chemotherapy, laparoscopic surgery was performed.OutcomesThe patient is alive until the submission of this paper.ConclusionWe presented a case of mucoepidermoid pancreatic cancer in a 65-year-old woman. Pathological examination revealed that the tumor parenchyma consisted of 3 cell types. There are mainly epidermoid cells, intermediate cells between the basal and epidermoid cells, and mucus-producing cells in varying proportions. Immunohistochemical staining showed that there were different types of cells with unique morphological characteristics. In summary, primary MECs of the pancreas are rare and have poor prognosis. Few studies have been conducted on the diagnosis, treatment, and metastasis of MECs; therefore, further studies are needed to detect them.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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