• Edoardo Conte, Silvia Tamanini, Emanuele Bizzi, Silvia Maestroni, Davide Cumetti, Maria Laura Novembre, Gianfranco Lauri, Cecilia Agalbato, CiaAlessia DallaADCentro Cardiologico Monzino IRCCS, Milan, Italy., Pasquale Paolisso, Gianluca Pontone, Mauro Pepi, Daniele Andreini, Massimo Imazio, George Lazaros, Alberto Benetti, and Antonio Brucato.
• Centro Cardiologico Monzino IRCCS, Milan, Italy; Department of Biomedical Science for Health, University of Milan, Milan, Italy. Electronic address: edoardo.conte86@gmail.com.
• Eur. J. Intern. Med. 2024 May 1; 123: 132137132-137.

IntroductionThe management of even large pericardial effusions in asymptomatic patients is still a matter of debate. Aim of the present study is to explore, in a multicenter setting, the rate of post-cardiac injury syndromes (PCIS) and pericardial effusion recurrence after pericardial effusion drainage procedure.Material And MethodsThis is a multicenter international retrospective study including a consecutive cohort of patients diagnosed with large, chronic and idiopathic pericardial effusions, prospectively evaluated from January 2003 to December 2021 who underwent a clinically indicated pericardial drainage procedure. Two separate end-points were recorded: 1) recurrence of pericardial effusion after drainage without any sign of pericardial inflammation 2) occurrence of PCIS, defined as the new onset of pericarditis 1 to 6 weeks after pericardial intervention.Results124 patients were enrolled (50 % female, mean age 64 years old). A mean follow-up of 29.6 ± 25.6 months was obtained in 110 patients (88 %). 110 patients were treated with pericardiocentesis (89 %), 25 with pleuro-pericardial windows (20 %), and 1 with pericardiectomy (1 %). PCIS occurred in 21 out of 124 patients followed for at least 6 weeks (16.9%). Recurrence of pericardial effusion after drainage without any sign of pericardial inflammation occurred in 68 out of 110 patients at a longer follow-up (61.8 %). At multivariate analysis only inflammatory cells in pericardial fluid was associated with PCIS and pericardiocentesis with pericardial effusion recurrency.ConclusionOur data support the need of caution with the use of pericardiocentesis in asymptomatic patients with large pericardial effusion as it is often associated with pericardial effusion recurrence. Of interest the presence of inflammatory cells in the pericardial fluid is associated with PCIS after pericardial drainage procedures.Copyright © 2024 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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