• Brenna Mossman, Laura M Perry, Hallie M Voss, Paul K Maciejewski, Robert Gramling, Paul Duberstein, Holly G Prigerson, Ronald M Epstein, and Michael Hoerger.
• Department of Psychology (B.M., H.M.V., M.H.), Tulane University, New Orleans, LA, USA.
• J Pain Symptom Manage. 2024 May 1; 67 (5): e393e398e393-e398.

ContextGender and personality may individually impact end-of-life care. Men often receive more aggressive treatments than women near death, and personality - particularly openness - may be associated with increased care utilization when it diverges from traditional treatment norms. However, research has not examined the interaction of these variables in a dyadic context.ObjectivesThis study examined the dyadic effects of patient gender and caregiver personality on end-of-life care.MethodsUsing data from the VOICE randomized clinical trial, the present sample consisted of patient-caregiver dyads receiving outpatient care for advanced cancer in Sacramento and Western New York. Analyses assessed whether caregiver personality was associated with gender-based differences in patient chemotherapy or emergency department/inpatient visits in the 30 days before death. Logistic regression examined the interaction between caregivers' Big Five personality dimensions and patient gender while accounting for patient and caregiver demographic and health characteristics.ResultsOf a total of 134 patient-caregiver dyads, 19.4% (n = 26) of patients received chemotherapy and 47.8% (n = 64) had an emergency department/inpatient visit in the 30 days before death. Results demonstrated a significant interaction between caregiver openness and patient gender on receipt of chemotherapy (odds ratio = 0.07, p = 0.006). When caregivers were less open, men were more likely to receive chemotherapy near death, whereas when caregivers were more open, women were more likely to receive chemotherapy near death.ConclusionResults suggest caregiver personality characteristics, particularly openness, might disrupt gender-based treatment norms at end-of-life. Findings demonstrate that patient and caregiver factors can interact to explain patient healthcare utilization.Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

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