• Medicina clinica · May 2024

    Review

    Portosinusoidal vascular disorder: A paradigm shift.

    • Luis Téllez, Jesús Donate, and Agustín Albillos.
    • Servicio de Gastroenterología y Hepatología. Hospital Universitario Ramón y Cajal, Madrid, España; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España; Centro de Investigación en Red Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, España; Universidad de Alcalá, Madrid, España. Electronic address: luis.tellez@salud.madrid.org.
    • Med Clin (Barc). 2024 May 17; 162 (9): 439447439-447.

    AbstractThe term portosinusoidal vascular disorder (PSVD) refers to a clinical-pathological entity that encompasses those patients with intrahepatic vascular damage without cirrhosis at risk of developing severe complications of portal hypertension. Numerous systemic diseases, genetic disorders, and toxic agents have been associated with this pathology, making its diagnosis an important clinical challenge. The recent description of uniform diagnostic criteria and a better understanding of its pathophysiology will allow for better identification of patients, even in early stages of the disease. Although there is currently no effective etiological treatment available, early diagnosis allows for the development of preventive strategies for some severe complications of portal hypertension.Copyright © 2023 Elsevier España, S.L.U. All rights reserved.

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