• Leevi A Toivonen, Heikki Mäntymäki, Lorin M Benneker, Hannu Kautiainen, Arja Häkkinen, and Marko H Neva.
• Department of Orthopedics and Traumatology, Tampere University Hospital and Tampere University, Tampere, Finland.
• Spine. 2024 Nov 15; 49 (22): E372E377E372-E377.

Study DesignRetrospective analysis of prospectively collected data.ObjectiveTo evaluate how preexisting adjacent segment degeneration status impacts revision risk for adjacent segment disease (ASD) after lumbar fusions.Summary Of Background DataASD incurs late reoperations after lumbar fusion surgeries. ASD pathogenesis is multifactorial. Preexisting adjacent segment degeneration, measured by Pfirrmann, is suggested as one of the predisposing factors. We sought to find deeper insights into this association by using a more granular degeneration measure, the combined imaging score (CIS).Patients And MethodsA total of 197 consecutive lumbar fusions for degenerative pathologies were enrolled in a prospective follow-up (median: 12 yr). Preoperative cranial adjacent segment degeneration status was determined using Pfirrmann and CIS, which utilize both radiographs and magnetic resonance imaging. On the basis of CIS, patients were trichotomized into tertiles (CIS <7, CIS 7-10, and CIS >10). The cumulative ASD revision risk was determined for each tertile. After adjusting for age, sex, body mass index, sacral fixation, and fusion length, hazard ratios (95% CI) for ASD revisions were determined for each Pfirrmann and CIS score.ResultsPatients in the intermediate CIS tertile had a cumulative ASD revision risk of 25.4% (17.0%-37.0%), while both milder degeneration (CIS <7) [13.2% (6.5%-25.8%)] and end-stage degeneration (CIS >10) [13.6% (7.0%-25.5%)] appeared to be protective against surgical ASD. Pfirrmann failed to show a significant association with ASD revision risk. Adjusted analysis of CIS suggested increased ASD revisions after CIS 7, which turned contrariwise after CIS 10.ConclusionsThe effect of preexisting adjacent segment degeneration on ASD reoperation risk is not linear. The risk appears to increase with advancing degeneration but diminishes with end-stage degeneration. Therefore, end-stage degenerative segments may be considered to be excluded from fusion constructs.Level Of EvidenceTherapeutic 3.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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