• Tao Yu, Hua-Yu Tang, Tian-Shu Wang, and Wei Wei.
• Second Ward of Orthopedis Department, First Affiliated Hospital of Jiamusi University, Jiamusi, China.
• Medicine (Baltimore). 2019 Aug 1; 98 (32): e16783e16783.

BackgroundThis study aims to investigate the effectiveness and safety of electrical stimulation (ES) for postoperative pain (PPP) in patients with osteosarcoma systematically.MethodsWe will systematically search the following electronic databases from inception to the May 1, 2019: MEDILINE, Cochrane Library, EMBASE, Web of Science, Springer, and CNKI without language restrictions. All literatures of randomized controlled trials (RCTs) and case-controlled studies (CCSs) of ES for PPP in patients with osteosarcoma will be included. RevMan 5.3 software (Cochrane Community; London, UK) and STATA 15.0 software (StataCorp; College Station) will be used for statistical analysis. Cochrane risk of bias will be used for methodological quality assessment for RCTs and Newcastle-Ottawa Scale will be utilized for CCSs.ResultsThis study will assess the clinical effectiveness and safety of ES for PPP in patients with osteosarcoma through assessing primary outcome of pain intensity and secondary outcomes of frequency of rescue analgesic use, cumulative morphine consumption, quality of recovery, as well as adverse events.ConclusionThis study will provide latest evidence on effectiveness and safety of ES for PPP in patients with osteosarcoma, and may also provide guidance for both clinician and further studies.Dissemination And EthicsThis study does not require ethical approval, because it will not analyze the individual patient data. Its results are expected to be published in peer-reviewed journals.Systematic Review RegistrationPROSPERO CRD42019135790.

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