• Hong Zhang, Ping Zhang, Hongbing Nie, Ji Zhang, Jie Li, Xiaoqing Lu, and Yaoyao Shen.
• Department of Neurology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi Province, China.
• Medicine (Baltimore). 2024 Feb 2; 103 (5): e37136e37136.

RationaleBilateral thalamic glioma is extremely rare and characterized by strictly limited involvement of bilateral thalami. To investigate its clinical and neuroimaging features, we herein reported a rare case of anaplastic astrocytoma (AA) involving both thalami and the brainstem and reviewed the literature.Patient ConcernsA-33-year-old Chinese woman was referred to our department owing to persistent headache and nausea and vomiting. Neurological examination showed mild cognitive impairment and positive Kernig sign.DiagnosisBrain magnetic resonance imaging (MRI) demonstrated asymmetrical and swollen lesions involving both thalami, midbrain and pontine tegmentum, without restricted diffusion or enhancement. On day 7 after admission, she was transferred to the department of neurosurgery and underwent a stereotactic brain biopsy of the right thalamic lesion. Histopathological features and immunohistochemistry were consistent with AA, IDH wild-type, World Health Organization grade III.InterventionsShe was administrated with mannitol and glycerin fructose for decreasing intracranial pressure.OutcomesIn spite of receiving chemotherapy, she died on 2-month after her initial diagnosis.LessonsAA involving in both thalami and brainstem is a rare entity with poor prognosis. The clinicians and radiologists should deepen their awareness of the specific MRI feature of bilateral thalamic involvement. When MRI alone is insufficient, the utility of stereotactic biopsy is essential for making a definitive diagnosis.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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