• Chia-Ju Liu, Jien-Jiun Chen, Jo-Hsuan Wu, Yao-Te Chung, Jin-Wun Chen, Meng-Tsun Liu, Chu-Hsuan Chiu, Yi-Cheng Chang, Sheng-Nan Chang, Jou-Wei Lin, and Juey-Jen Hwang.
• Department of Nuclear Medicine, National Taiwan University Hospital, Taipei City, Taiwan.
• J Formos Med Assoc. 2024 Sep 1; 123 (9): 968974968-974.

BackgroundExosomes are membrane vesicles that are actively secreted in response to microenvironmental stimuli. In this study, we quantified the amount of exosomes in patients with significant coronary artery disease (CAD) and evaluated its relationship with myocardial perfusion imaging (MPI) results.MethodsPatients who underwent both MPI and coronary angiography were recruited. Plasma was collected during angiography, and exosomes were extracted via the precipitation method. The summed stress scores (SSS), summed difference scores, and ventricular functional parameters were calculated from the MPI and compared with the amounts of exosomes and extracted miRNAs.ResultsIn total, 115 patients were enrolled (males: 78 %; mean age: 66.6 ± 10.6 years). Those with abnormal SSS according to the MPI had significantly fewer exosomes (p = 0.032). After multivariate analysis, the SSS remained significantly related to the amount of exosomes (p = 0.035). In forty randomly selected samples, miRNA-432-5p and miRNA-382-3p were upregulated in patients with abnormal SSS.ConclusionPatients with compromised poststress myocardial perfusion on MPI tended to have fewer exosomes in association with CAD-related miRNAs. This is the first study to clarify the fundamental and pathophysiological causes of CAD using radiographic examinations.Copyright © 2024 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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