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J. Korean Med. Sci. · Jan 2024
ReviewAntibiotic Resistance of Helicobacter pylori: Mechanisms and Clinical Implications.
- Md Hasanuzzaman, Chang Seok Bang, and Eun Jeong Gong.
- Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.
- J. Korean Med. Sci. 2024 Jan 29; 39 (4): e44e44.
AbstractHelicobacter pylori is a pathogenic bacterium associated with various gastrointestinal diseases, including chronic gastritis, peptic ulcers, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. The increasing rates of H. pylori antibiotic resistance and the emergence of multidrug-resistant strains pose significant challenges to its treatment. This comprehensive review explores the mechanisms underlying the resistance of H. pylori to commonly used antibiotics and the clinical implications of antibiotic resistance. Additionally, potential strategies for overcoming antibiotic resistance are discussed. These approaches aim to improve the treatment outcomes of H. pylori infections while minimizing the development of antibiotic resistance. The continuous evolution of treatment perspectives and ongoing research in this field are crucial for effectively combating this challenging infection.© 2024 The Korean Academy of Medical Sciences.
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