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Case Reports
Acute Liver Injury and Bilateral Pulmonary Artery Thrombosis due to Hypereosinophilic Syndrome: A Case Report.
- Keishi Ouchi, Hiromasa Okamoto, Jun Inoue, Shigeyuki Kobayashi, Hiroshi Nagai, Daisuke Okamoto, Tomoo Manaka, Yoshihiro Nozawa, and Atsushi Masamune.
- Department of Gastroenterology, Shirakawa Kosei General Hospital, Japan.
- Intern. Med. 2024 Sep 1; 63 (17): 241524202415-2420.
AbstractA 46-year-old Japanese man was referred to our hospital because of a marked increase in his eosinophil count (22,870/μL) and elevated liver enzyme levels. Computed tomography (CT) showed thrombi measuring approximately 8 cm in both femoral veins. A liver biopsy revealed eosinophilic infiltration, hepatocyte necrosis, fibrosis, and multiple thrombi. We suspected acute liver injury and deep vein thrombosis associated with hypereosinophilic syndrome and initiated steroids and heparin treatment. Four days after starting treatment, the patient experienced sudden chest pain and cardiopulmonary arrest. CT revealed bilateral pulmonary artery thrombosis, and despite administration of a tissue plasminogen activator, the patient died.
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