• Internal medicine · Nov 2024

    Case Reports

    Autopsy of a 45-year-old Man with Liver Failure Due to Polycystic Liver Disease.

    • Masato Mizuta, Akinari Sekine, Tatsuya Suwabe, Junichi Hoshino, Masayuki Yamanouchi, Hiroki Mizuno, Daisuke Ikuma, Eiko Hasegawa, Yuki Oba, Kei Kono, Keiichi Kinowaki, Kenichi Ohashi, Naoki Sawa, and Yoshifumi Ubara.
    • Nephrology Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Kajigaya, Japan.
    • Intern. Med. 2024 Nov 1; 63 (21): 296529702965-2970.

    AbstractA 37-year-old man with autosomal dominant polycystic kidney disease (ADPKD) was admitted to our hospital with a liver volume of 8,000 cm3. Hepatic arterial embolization was performed using a microcoil but was ineffective. Eight years later, the hepatomegaly progressed to liver failure and death. At autopsy, the liver weighed 21.5 kg, and the entire liver had been replaced by cysts; in the few remaining areas of liver parenchyma, microscopic, small cysts of various sizes and fibrosis were evident, with only a few normal hepatocytes observed. Hepatic arterial branches developed; however, the portal vein could not be observed.

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