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- Tetsuya Ishikawa, Yasuaki Tatsumi, Koichi Kato, Yumi Hayashi, Norihiro Imai, Takanori Ito, Yoji Ishizu, Masatoshi Ishigami, Wataru Nihei, Ayako Kato, and Hisao Hayashi.
- Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Japan.
- Intern. Med. 2024 Sep 1; 63 (17): 242124252421-2425.
AbstractA 59-year-old Japanese woman presented with hyperferritinemia. We decided against iron removal treatment because there were no symptoms or signs of iron-induced organ damage. A follow-up study revealed a gradual increase in transferrin saturation. The patient underwent a second examination at 66 years old. A liver biopsy showed substantial iron deposits in hepatocytes and Kupffer cells but no inflammation or fibrosis. Serum hepcidin-25 levels were highly parallel with hyperferritinemia. A genetic analysis revealed a G80S mutation in SLC40A1. These features are compatible with those of ferroportin disease. The patient remained asymptomatic at 70 years old, suggesting that the iron-loading condition may have been benign.
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