• Brit J Hosp Med · Jan 2024

    Monitoring thyroid function during amiodarone use.

    • Priya Sharma, Riyad Sheikh, Nipuna Siribaddana, Abilash Sathyanarayanan, Devaka Fernando, and Vakkat Muraleedharan.
    • Department of Diabetes and Endocrinology, King's Mill Hospital, Sutton-in-Ashfield, UK.
    • Brit J Hosp Med. 2024 Jan 2; 85 (1): 151-5.

    AbstractAmiodarone is an antiarrhythmic drug used to treat cardiac tachyarrhythmias. It has many adverse effects, with thyroid dysfunction one of the most notable. Through various mechanisms, both thyrotoxicosis and hypothyroidism can occur secondary to amiodarone therapy. There are two types of amiodarone-induced thyrotoxicosis: type 1 occurs in those with pre-existing thyroid disease and is treated with thionamide, whereas type 2 occurs in those without and is treated with glucocorticoids. Patients with amiodarone-induced hypothyroidism may be given levothyroxine to replace thyroid hormone, but in some cases, the appropriate management may be cessation of amiodarone.

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