• Miguel Sánchez-García, Manuel Álvarez-González, Sara Domingo-Marín, Pino-RamírezÁngela DelÁDCritical Care Department, Hospital Clínico San Carlos, Madrid, Spain., Fernando Martínez-Sagasti, Paloma González-Arenas, Carlos Cardenal-Sánchez, Elena Velasco-López, and Antonio Núñez-Reiz.
• Critical Care Department, Hospital Clínico San Carlos, Madrid, Spain. miguelsanchez.hcsc@gmail.com.
• Respir Care. 2024 Apr 22; 69 (5): 575585575-585.

BackgroundOpen respiratory secretion suctioning with a catheter causes pain and tracheobronchial mucosal injury in intubated patients. The goal of mechanical insufflation-exsufflation (MI-E) is to move secretions proximally and noninvasively by generating a high peak expiratory air flow. Nebulized hypertonic saline with hyaluronic acid (HS-HA) may facilitate suctioning by hydration. We assessed the safety and tolerance of a single session of airway clearance with MI-E and HS-HA in critically ill intubated patients.MethodsAdults with a cuffed artificial airway were randomized to (1) open suctioning, (2) open suctioning after HS-HA, (3) MI-E, or (4) MI-E with HS-HA. Adverse events, pain and sedation/agitation scores, and respiratory and hemodynamic variables were collected before, during, and 5-min and 60-min post intervention.ResultsOne-hundred twenty subjects were enrolled and completed the study. Median (interquartile range [IQR]) Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 22 (16-28); median (IQR) age was 69.0 (57.0-75.7) y, and 90 (75%) were male. Baseline respiratory and hemodynamic variables were comparable. Adverse events occurred in 30 subjects (25%), with no between-group differences. Behavioral pain equivalents and Richmond Agitation-Sedation Scale were higher during suctioning in groups 1 (P < .001) and 2 (P < .001). Independent predictive variables for higher pain and agitation/sedation scores were study groups 1 and 2 and simultaneous analgosedation, respectively. Noradrenaline infusion rates were lower at 60 min in groups 2 and 4. PaO2 /FIO2 had decreased at 5 min after open suctioning in group 1 and increased at 60 min in group 3.ConclusionsWe observed no difference in adverse events. MI-E avoids pain and agitation.Copyright © 2024 by Daedalus Enterprises.

7 keywords...

hide…