• Ramesh Omranipour, Mehrshad Abassi, Newsha Nazarian, Bardia Gholami, Samareh Heydari, Bita Eslami, Alireza Abdollahi, and Sadaf Alipour.
• Breast Disease Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
• Arch Iran Med. 2023 Nov 1; 26 (11): 618622618-622.

BackgroundSentinel lymph node biopsy (SLNB) with injection of radiopharmaceuticals is now the standard of care for staging the axilla in patients with breast cancer. Sulfur or antimony colloids labeled with 99mTechnetium (Tc) are used globally for the procedure, with a detection rate of 94%. However, in Iran, Tc phytate has been used because it is more easily producible in the country. The detection rate with Tc phytate has not been well determined in large-scale studies. Objective: We performed this study to report the detection rate of SLNB with Tc phytate, its advantages and disadvantages using large multicentric data.MethodsThis is a retrospective cross-sectional multicenter study. Participants were breast cancer patients without previous history of axillary surgery, who underwent sentinel node biopsy using Tc phytate on the morning of surgery or the day before. The detection rate was calculated as the number of patients with histologically positive sentinel nodes to all patients with histologically positive lymph nodes; we compared those injected on the day of surgery and those injected on the day before.ResultsOverall, 2663 women aged 50.2±11.6 years were included. The detection rate was 91.8% (806 out of 878). The false negative rate was 8.2% overall, and statistically similar for injections on the day or the day before surgery (2.9 vs 2.1; P=0.32).ConclusionTc phytate has a good detection rate for breast radio-guided SLNB with similar result for injections on the surgery day or the day before it.© 2023 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

21 keywords...

hide…