• Clinics · Jan 2024

    Expression and clinical significance of miR-141-5p as a biomarker in the serum of patients with early spontaneous abortion.

    • XiaoQun Che, Xiao Wang, LiLian Wang, LiHua Xu, Lin Zou, TianZhong Ma, and Bi Chen.
    • Department of Reproductive Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang City, Guangdong Province, China; Department of Reproductive Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong Province, 528300, China.
    • Clinics (Sao Paulo). 2024 Jan 1; 79: 100327100327.

    AimmiR-141-5p expression in patients with Early Spontaneous Abortion (ESA) and its correlation with hormone levels during pregnancy were investigated.MethodsA total of 70 pregnant women with ESA were selected as the research group, and 70 normal pregnant women who chose abortion for non-medical reasons were selected as the Con group. Serum β-HCG, Progesterone (P), and Estrogen (E2) were detected by enzyme-linked immunosorbent assay. Differentially expressed miRNAs were screened by miRNA microarray analysis. miR-141-5p expression was detected by RT-qPCR, and its correlation with serum β-HCG, P, and E2 levels was analyzed. The diagnostic value of miR-141-5p for ESA was evaluated by the ROC curve.ResultsSerum β-HCG, P, and E2 were decreased and serum miR-141-5p was increased in patients with ESA. Pearson correlation analysis showed that serum β-HCG, P, and E2 levels were negatively correlated with miR-141-5p expression levels. ROC curve showed that miR-141-5p had a diagnostic value for ESA.ConclusionsmiR-141-5p is related to hormone levels during pregnancy and is expected to become a new candidate diagnostic marker for ESA.Copyright © 2024 HCFMUSP. Published by Elsevier España, S.L.U. All rights reserved.

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