• Ann. Intern. Med. · Feb 2024

    Comment Randomized Controlled Trial

    In primary care, second-line IBS therapy with amitriptyline vs. placebo reduced symptoms at 6 mo.

    • Tanvi Gupta and Brooks D Cash.
    • University of Texas Health Science Center at Houston, Houston, Texas, USA (T.G., B.D.C.).
    • Ann. Intern. Med. 2024 Feb 1; 177 (2): JC15JC15.

    AbstractFord AC, Wright-Hughes A, Alderson SL, et al; ATLANTIS trialists. Amitriptyline at low-dose and titrated for irritable bowel syndrome as second-line treatment in primary care (ATLANTIS): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet. 2023;402:1773-1785. 37858323.

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