• Kai-Uwe Kern, Tamara Quandel, Sina Theis, and Tino Schubert.
• Institute of Pain Medicine/Pain Practice, Wiesbaden, Germany.
• Pain Pract. 2024 Jun 1; 24 (5): 700708700-708.

ObjectiveThe aim of this study was to evaluate patient characteristics, concomitant analgesic medication, and pain intensity in a real-world setting in Germany, focusing on the repeated application of high-concentration capsaicin patch (HCCP) for neuropathic pain.DesignData were collected from electronic medical records of patients who received at least two HCCP treatments between January 2011 and July 2022. Subgroup analyses were performed based on the number of HCCP treatments, age groups, and specific neuropathic pain conditions.SettingThe study was conducted at an outpatient pain center in Wiesbaden, Germany.SubjectsThe study included 97 patients, primarily diagnosed with neuropathic back pain, postoperative or post-traumatic neuropathic pain, and postherpetic neuralgia.MethodsThe daily dose of concomitant medications (eg, opioids and anticonvulsants) at the start of capsaicin therapy was compared with the average within 2 years of capsaicin therapy. The last observation carried forward method was used if HCCP treatment was discontinued before the end of the 2-year period.ResultsThe majority of patients received concomitant medications, with opioids, anticonvulsants, and antidepressants being the most common. The average daily morphine equivalent dose decreased significantly during HCCP treatment. Pain intensity at baseline was generally high, but substantial improvements were observed in patients who received at least three HCCP applications.ConclusionsThis study provides evidence for the effectiveness of HCCP treatment in reducing pain intensity and concomitant opioid use in patients with neuropathic pain. Further research is needed to explore the long-term outcomes and optimal treatment regimens for different patient populations.© 2024 The Authors. Pain Practice published by Wiley Periodicals LLC on behalf of World Institute of Pain.

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