• Jun Liu, Tingting Shen, Long Li, Xingyi Li, Fang Zhao, Xiaoxia Liu, Shan Zhang, Pengjia Wu, Na Li, and Jiashun Zeng.
• Department of Rheumatology and Immunology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
• Medicine (Baltimore). 2024 Feb 9; 103 (6): e36999e36999.

RationaleWhile some systemic lupus erythematosus (SLE) patients may experience varying degrees of liver function abnormalities, only a small portion of these cases have clinical significance, and the majority of patients typically exhibit low levels of serum bilirubin. However, in this article, we present a case of a middle-aged female patient with SLE who exhibited persistent skin jaundice as her initial symptom, offering a fresh perspective on diagnosing and treating patients who exhibit unexplained liver dysfunction and SLE combined with liver injury.Patient ConcernsA 45-year-old woman was initially admitted to the hospital due to yellowing of the skin and sclera, and her symptoms did not improve significantly during treatment. The results were abnormal after relevant immunological tests.DiagnosesPersistent non-conjugated bilirubin elevation due to lupus hepatitis.InterventionsThe use of methylprednisolone sodium succinate (40 mg/Qd) and mycophenolate mofetil (0.75 g/d) suppressed immunity, polyolefin choline (20 mL/d) and glutathione (0.6 g/Qd) improved liver function, and nutritional support therapy.OutcomesAfter 2 weeks of treatment, a significant decrease in the yellow skin and sclera of the patient was observed.LessonsMost clinicians overlook that liver function abnormalities are the main manifestation of SLE, resulting in many patients not receiving timely treatment. This study highlights the importance that SLE is also a cause of abnormal liver function.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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