• Xianfeng Rao, Zhengwen Kang, Jianwei Chen, Tong Wang, Mengyao Ma, Shuwen Yang, Zetao Wu, Bo Wang, and Qiusheng Zhang.
• Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen University First Affiliated Hospital, Clinical College of Shantou University Medical College, Shenzhen, China.
• Medicine (Baltimore). 2024 Feb 9; 103 (6): e37097e37097.

IntroductionCellular blue nevus is an uncommon neoplasm in the spine.Patient ConcernsHere, we present a case of a 24 years old male with a 2 months history of numbness in the right upper limb and shoulder.DiagnosisCervical spine and subcutaneous tissue invasive cellular blue nevus.InterventionsThe patient underwent C4 laminectomy and partial C3 and C5 laminectomy for total resection of the lesion. Histopathology revealed a nodular tumor with unclear boundaries, which was composed of heavily pigmented dendritic cells and more pigmented spindle cells.OutcomesThere was no recurrence during 3 years follow-up.ConclusionInvasive cellular blue nevus of the spine can be wrongly diagnosed as spinal meningeal melanocytoma and meningeal melanoma due to its special cell behavior and rarity. Therefore, it is important to understand its pathological and clinical characteristics to avoid over-treatment.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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