• Yupei Shao, Hong Lv, Weixun Zhou, Baotong Zhou, Qingwei Jiang, and Jiaming Qian.
• Department of Gastroenterology.
• Medicine (Baltimore). 2024 Feb 9; 103 (6): e37195e37195.

RationaleAmebic colitis has been less prevalent in recent times in China, and the similarity of its symptoms to those of inflammatory bowel disease (IBD) results in the difficulty of early identification and diagnosis.Patient ConcernsA 31-year-old male who exhibited intermittent diarrhea and hematochezia was highly suspected as IBD initially. Despite the partial relief of symptoms following the administration of mesalamine, the endoscopic ulcers remained largely unchanged.DiagnosesTwo years after the onset of mesalamine therapy, amebic cysts were detected in stool microscopy and trophozoites were found on the surface of cecal ulcers. The patient was then diagnosed with amebic colitis.InterventionsAfter 2 rounds of standardized metronidazole treatment, amebic colitis remained refractory until diloxanide was administered.OutcomesThe patient remained asymptomatic, and the mucosa of colon was normal during the annual follow-up.LessonsIndividuals newly diagnosed with IBD should undergo essential screening for amebiasis. And the use of steroids should be taken with caution, especially in cases where the effect of mesalamine is limited. For symptomatic intestinal amebiasis, even after the administration of tissue amebicides, the continued use of luminal amebicides is necessary to prevent recurrence.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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