Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
Cell Metab. 2016 Jun 14; 23 (6): 106010651060-1065.
Abstract Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.Copyright © 2016. Published by Elsevier Inc.
Metformin and anti-aging .
You can also include formatting, links, images and footnotes in your notes
Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
Links can be included with: [my link to pubmed](http://pubmed.com)
Images can be included with: 
For footnotes use [^1](This is a footnote.) inline.
Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..