• Br J Anaesth · Mar 2024

    Editorial

    Danavorexton (TAK-925): an orexin receptor 2 agonist as a new 'arousal' agent.

    • David G Lambert and Kazuyoshi Hirota.
    • Department of Cardiovascular Sciences, Anaesthesia, Critical Care and Pain Management, University of Leicester, Hodgkin Building, Leicester, UK. Electronic address: dgl3@le.ac.uk.
    • Br J Anaesth. 2024 Mar 1; 132 (3): 466468466-468.

    AbstractA preclinical study in animals has further characterised a new 'arousal' agent. Danavorexton (TAK-925) is an agonist for orexin receptor 2 where it promotes recovery from inhalational and i.v. anaesthesia and opioid sedation. Although danavorexton reverses opioid sedation, it does not compromise analgesia. This could be a useful addition to the postoperative drug cupboard.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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