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- Kosuke Suzuki, Takuya Ataka, Noriyuki Kimura, and Etsuro Matsubara.
- Department of Neurology, Oita University Faculty of Medicine, Japan.
- Intern. Med. 2024 Sep 15; 63 (18): 254725502547-2550.
AbstractWe herein report the a 42-year-old man with early-onset cerebral amyloid angiopathy (CAA) and a history of traumatic brain injury and neurosurgery in childhood. Computed tomography revealed cognitive impairment and recurrent lobar intracerebral hemorrhaging. Magnetic resonance imaging indicated cerebral microbleeds, and Pittsburgh compound B positron emission tomography detected brain amyloid deposition, mainly in the region of trauma and occipital lobes. Interestingly, the patient had no genetic predispositions or relevant family history. This case suggests that a single traumatic brain injury or neurosurgery in childhood can cause early-onset CAA.
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