• Yujing Wang, Na Wang, Xuejiao Zhang, Zijie Fu, Chao Pang, Yuan Zhang, and Xiaodong Li.
• Department of Gynecology, The First Hospital of Hebei Medical University, 050030, Shijiazhuang, China.
• Medicine (Baltimore). 2024 Feb 16; 103 (7): e37069e37069.

IntroductionAdult-type granulosa cell tumors (AGCTs), which account for 2% to 5% of all malignant ovarian tumors, are rare sex cord-stromal tumors that usually secrete excess estrogens, but they can also secrete androgens.Patient ConcernsWe report 2 patients of childbearing age with AGCT who presented with the complaint of abnormal menstruation and elevated luteinizing hormone (LH), and mildly elevated testosterone.DiagnosisThe ovarian tumors had hormonal activity.InterventionsThe 2 patients underwent laparoscopic left adnexectomy. The second patient underwent 4 cycles of chemotherapy with paclitaxel and carboplatin as adjuvant treatments.OutcomesTheir postoperative pathology confirmed AGCTs. Also, their menstrual cycle returned to normal, with normal serum LH and testosterone levels. There was no sign of recurrence.ConclusionThe cases suggest that elevated serum LH levels may be a sign of unknown tumors in cases of oligomenorrhea or secondary amenorrhea. It is useful to evaluate the serum levels of inhibin B and anti-Müllerian hormone to improve the early recognition of ovarian granulosa cell tumors.Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.

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