• Resuscitation · May 2024

    Multicenter Study Observational Study

    The association between mechanical CPR and outcomes from in-hospital cardiac arrest: An observational cohort study.

    • Conor Crowley, Justin Salciccioli, Wei Wang, Tomoyoshi Tamura, Edy Y Kim, Ari Moskowitz, and American Heart Association's Get With The Guidelines® – Resuscitation Investigators.
    • Division of Pulmonary and Critical Care Medicine, Lahey Hospital and Medical Center, Burlington, MA 01805, USA; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Tufts University School of Medicine, Boston, MA 02111, USA. Electronic address: conor.p.crowley@lahey.org.
    • Resuscitation. 2024 May 1; 198: 110142110142.

    AimWe sought to investigate the relationship between mechanical cardiopulmonary resuscitation (CPR) during in-hospital cardiac arrest and survival to hospital discharge.MethodsUtilizing the prospectively collected American Heart Association's Get With The Guidelines database, we performed an observational study. Data from 153 institutions across the United States were reviewed with a total of 351,125 patients suffering cardiac arrest between 2011 and 2019 were screened. After excluding patients with cardiac arrests lasting less than 5 minutes, and patients who had incomplete data, a total of 111,143 patients were included. Our primary exposure was mechanical vs. manual CPR, and the primary outcome was survival to hospital discharge. Multivariate logistic regression models and propensity weighted analyses were used.Results11.8% of patients who received mechanical CPR survived to hospital discharge versus 16.9% in the manual CPR group. Patients who received mechanical CPR had a lower probability of survival to discharge compared to patients who received manual CPR (OR 0.66 95% CI 0.58-0.75; p < 0.001). This association persisted with multi-variable adjustment (OR 0.57 95% CI 0.46-0.70, p < 0.0001) and propensity weighted analysis (OR 0.68 95% CI 0.44-0 0.92, p < 0.0001). Mechanical CPR was associated with decrease likelihood of return of spontaneous circulation after multivariate adjustment (OR 0.68, 95% CI 0.60-0.76; p < 0.001).ConclusionsMechanical CPR was associated with a decreased likelihood of survival to hospital discharge and ROSC compared to manual CPR. This finding should be interpreted within the context of important limitations of this study and randomized trials are needed to better investigate this relationship.Copyright © 2024 Elsevier B.V. All rights reserved.

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