• WongGeoffrey Yuet MunGYMRoyal North Shore Hospital, St Leonards, Australia., Himanshu Wadhawan, Roth CardosoVictorVUniversity of Birmingham, Birmingham, United Kingdom., Laura Bravo Merodio, Yashasvi Rajeev, Ricardo David Maldonado, Alessandro Martinino, Vignesh Balasubaramaniam, Aabid Ashraf, Adeela Siddiqui, Ahmad Ghassan Al-Shkirat, Ahmed Mohammed Abu-Elfatth, Ajay Gupta, Akram Alkaseek, Amel Ouyahia, Amira Said, Anshuman Pandey, Ashwani Kumar, Baila Maqbool, Carlos Alberto Millán, Cheena Singh, Diana Alejandra Pantoja Pachajoa, Dmitry Mikhailovich Adamovich, Enrique Petracchi, Fariha Ashraf, Marco Clementi, Francesk Mulita, Gad Amram Marom, Gamaleldeen Abdulaal, Georgios-Ioannis Verras, Giacomo Calini, Gianluigi Moretto, Hossam Elfeki, Hui Liang, Humam Jalaawiy, Ibrahim Elzayat, Jayanta Kumar Das, Jose Miguel Aceves-Ayala, Kazi T Ahmed, Luca Degrate, Manisha Aggarwal, Mohammed Ahmed Omar, Mounira Rais, Muhammed Elhadi, Nasser Sakran, Rajesh Bhojwani, Ramesh Agarwalla, Samir Kanaan, Sarnai Erdene, Serge Chooklin, Suhail Khuroo, Surrendar Dawani, Syed Tanseer Asghar, Tak Kwan James Fung, Taryel Omarov, Valentin Titus Grigorean, Zdenko Boras, V GkoutosGeorgiosGCentre for Health Data Science, University of Birmingham, United Kingdom., Rishi Singhal, Kamal Mahawar, and AMBROSE Collaborative.
• Royal North Shore Hospital, St Leonards, Australia.
• Ann. Surg. 2024 Feb 13.

ObjectiveThis study aimed to assess 30-day morbidity and mortality rates following cholecystectomy for benign gallbladder disease and identify the factors associated with complications.Summary Background DataAlthough cholecystectomy is common for benign gallbladder disease, there is a gap in the knowledge of the current practice and variations on a global level.MethodsA prospective, international, observational collaborative cohort study of consecutive patients undergoing cholecystectomy for benign gallbladder disease from participating hospitals in 57 countries between January 1 and June 30, 2022, was performed. Univariate and multivariate logistic regression models were used to identify preoperative and operative variables associated with 30-day postoperative outcomes.ResultsData of 21,706 surgical patients from 57 countries were included in the analysis. A total of 10,821 (49.9%), 4,263 (19.7%), and 6,622 (30.5%) cholecystectomies were performed in the elective, emergency, and delayed settings, respectively. Thirty-day postoperative complications were observed in 1,738 patients (8.0%), including mortality in 83 patients (0.4%). Bile leaks (Strasberg grade A) were reported in 278 (1.3%) patients and severe bile duct injuries (Strasberg grades B-E) were reported in 48 (0.2%) patients. Patient age, ASA physical status class, surgical setting, operative approach and Nassar operative difficulty grade were identified as the five predictors demonstrating the highest relative importance in predicting postoperative complications.ConclusionThis multinational observational collaborative cohort study presents a comprehensive report of the current practices and outcomes of cholecystectomy for benign gallbladder disease. Ongoing global collaborative evaluations and initiatives are needed to promote quality assurance and improvement in cholecystectomy.Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.

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