• Cochrane Db Syst Rev · Jul 2007

    Review

    WITHDRAWN: Bromocriptine for unexplained subfertility in women.

    • E Hughes, J Collins, and P Vandekerckhove.
    • McMaster University, Rm HSC-4F7, Dept of Obstetrics & Gynecol, 1200 Main St West, Hamilton, Ontario, Canada, L8N 3Z5. hughese@mcmaster.ca
    • Cochrane Db Syst Rev. 2007 Jul 18; 1996 (4): CD000044CD000044.

    BackgroundBromocriptine improves hyperprolactinemic amenorrhea and so could also be helpful in the treatment of unexplained subfertility in women.ObjectivesTo assess the effects of bromocriptine in women with unexplained subfertility.Search StrategyThe Cochrane Subfertility Review Group specialised register of controlled trials was searched.Selection CriteriaRandomised trials comparing bromocriptine with placebo or no treatment in women with unexplained subfertility.Data Collection And AnalysisTwo reviewers applied the eligibility criteria and assessed trial quality independently.Main ResultsThree trials involving of 127 women were included. All trials were double-blind comparisons with placebo, and one was of crossover design. Conception rates with bromocriptine treatment did not improve compared with placebo (odds ratio was 1.12, 95% confidence interval 0.48 to 2.57).Authors' ConclusionsThere is not enough evidence to evaluate bromocriptine use in women with unexplained subfertility. However trials for women with unexplained subfertility who also have expressible galactorrhea may be worthwhile.

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