• J R Scott and N Pattison.
• Cochrane Db Syst Rev. 1996 Apr 22; 1996 (1): CD000101CD000101.

BackgroundThere may be an association between recurrent miscarriage and abnormal hormone function in the follicular phase. Human chorionic gonadotrophin may play a role in preventing miscarriages.ObjectivesThe objective of this review was to assess the effects of human chorionic gonadotrophin administration during early pregnancy on the risk of miscarriage in women with a history of recurrent miscarriage.Search StrategyThe Cochrane Pregnancy and Childbirth Group trials register was searched. Date of last search: 9 January 1998.Selection CriteriaRandomised trials of human chorionic gonadotrophin compared with placebo or no treatment in women who have had two or more miscarriages.Data Collection And AnalysisEligibility and trial quality were assessed by one reviewer.Main ResultsFour trials involving 180 women were included. The trials were of variable quality. Human chorionic gonadotrophin was associated with a reduced risk of miscarriage for women with a history of recurrent miscarriage (odds ratio 0.26, 95% confidence interval 0.14 to 0.52). This result should be interpreted cautiously because the apparent effect is greatly influenced by the two methodologically weaker studies.Authors' ConclusionsThere is not enough evidence to evaluate the use of human chorionic gonadotrophin during pregnancy in order to prevent miscarriage in women with a history of unexplained recurrent spontaneous miscarriage.

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