• Internal medicine · Sep 2024

    Case Reports

    Ventral Variant Posterior Cortical Atrophy with Occipito-temporal Accumulation of Tau Proteins/Astrocyte Gliosis.

    • Mihoko Shiio, Nobuya Maeda, Atsushi Iwata, Kenji Ishibashi, Kenji Ishii, Hiroshi Takuma, Yuko Ishizaka, and Yasuhisa Sakurai.
    • Department of Neurology, Omori Red Cross Hospital, Japan.
    • Intern. Med. 2024 Sep 15; 63 (18): 255525652555-2565.

    AbstractA 73-year-old woman with posterior cortical atrophy (PCA) presented with progressive apperceptive visual agnosia, alexia, agraphia, ventral simultanagnosia, prosopagnosia, and allocentric (stimulus-centered) left-sided hemispatial neglect. All of these symptoms were attributed to damage to the bilateral occipito-temporal cortices, consistent with ventral variant PCA. While the Pittsburgh compound B uptake was extensively distributed throughout the occipito-parietal (dorsal) and occipito-temporal (ventral) areas, the THK5351 (ligand binding to tau aggregates/astrocyte gliosis) accumulation was limited to the ventral area. These findings suggest that local accumulation of tau proteins and/or astrocyte gliosis over the occipito-temporal cortices can result in ventral variant PCA.

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