• Anacássia Fonseca Lima, Lívia Bandeira Costa, Joás Lucas da Silva, Maria Bernadete Sousa Maia, and Eulália Camelo Pessoa Azevedo Ximenes.
• Microorganism Physiology and Biochemistry Laboratory, Universidade Federal de Pernambuco, Recife, Brazil. cassialima3@hotmail.com
• Sao Paulo Med J. 2011 May 1; 129 (3): 165170165-70.

Context And ObjectiveStaphylococcus aureus is the most frequent agent isolated in diabetic foot infections and may be associated with changes to wound healing times. The aim of this study was to perform a systematic review of the literature, including studies that assessed the efficacy of any clinical or surgical intervention, as well as oral or topical therapy for diabetic ulcers infected with S. aureus.Design And SettingSystematic review with a search conducted in databases.MethodsWe conducted a systematic review with a comprehensive search in the Lilacs, SciELO, PubMed/Medline, Old Medline, Embase and Cochrane Library databases, for articles published from 1966 to 2010. The articles selected were limited to studies on diabetic patients with wounds infected with S. aureus for whom their healing was followed up, with the use of either antibiotics or experimental treatments. Animal studies and those that did not report the wound healing, as well as review articles, were excluded.ResultsFive studies that met the inclusion and exclusion criteria were analyzed.ConclusionsThere are few studies reporting the healing of wounds infected with S. aureus in diabetic patients, although this is the most commonly found pathogen in this type of wound and it frequently consists of methicillin-resistant S. aureus (MRSA). There is insufficient evidence to support early use of broad-spectrum antibiotics against MRSA to promote healing of diabetic ulcers, since antibiotic resistance may develop from such treatment. This highlights the need for further studies on the subject.

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