• Marina de Pádua Nogueira Menezes, Celina Tizuko Fujiyama Oshima, Levon Badiglian Filho, Thiago Simão Gomes, Luis Fernando Mesias Barrezueta, João Norberto Stávale, and Wagner José Gonçalves.
• Gynecological Oncology Sector, Department of Gynecology, Universidade Federal de São Paulo-Escola Paulista de Medicina, São Paulo, Brazil. marinapnogueira@yahoo.com.br
• Sao Paulo Med J. 2011 Jan 1; 129 (5): 320324320-4.

Context And ObjectiveThe Wnt pathway is involved in tumorigenesis of several tissues. For this reason, we proposed to evaluate Wnt gene expression in endometrial cancer type I.Design And SettingCross-sectional study on materials gathered from the tissue bank of the Department of Pathology, Universidade Federal de São Paulo.MethodsEndometrial specimens were obtained from surgeries performed between 1995 and 2005 at São Paulo Hospital, Universidade Federal de São Paulo. The material was divided into two groups according to tissue type: Group A, atrophic endometrium (n = 15); and Group B, endometrial adenocarcinoma (n = 45). We compared the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and beta-catenin between endometrial cancer type I and atrophic endometrium.ResultsRegarding Wnt1, FZD1 and Wnt5a expression, no significant association was observed between the groups. A significant association was observed between the groups in relation to FZD5 expression (P = 0.001). The proportion of FZD5-positive samples was significantly higher in group A (80.0%) than in group B (31.1%). Regarding the survival curve for FZD5 in group B, we did not find any significant association between atrophic endometrium and endometrial adenocarcinoma. We also did not find any significant association regarding beta-catenin expression (P = 1.000).ConclusionFZD5 is downregulated in endometrial adenocarcinoma, in comparison with atrophic endometrium.

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